Q. No.The first clinical gene therapy was given for treating
(1) diabetes mellitus
(2) chickenpox
(3) rheumatoid arthritis
(4) adenosine deaminase deficiency
The protein products of the following Bt toxin genes cry I Ac and cry II Ab are responsible for controlling
(1) bollworm
(2) roundworm
(3) moth
(4) fruit fly
Three critical research areas of biotechnology are:
I. Providing the best catalyst in the form of improved organism usually a microbe or pure enzyme
II. Multiple Ovulation Transfer Technology (MOET)
III. Creating optimal conditions through engineering for a catalyst to act.
IV. Downstream processing technologies
(1) I, II, III, IV
(2) I, III, IV
(3) I, II
(4) II and IV
Bt toxin is:
(1) Intracellular lipids
(2) Intracellular crystalline protein
(3) Extracellular crystalline protein
(4) Intracellular polysaccharide
Bt toxin is harmful to insects like:
(1) Lepidoterans (tobacco budworm, armyworms)
(2) Coleopterans (beetles)
(3) Dipterans (flies and mosquito)
(4) All are correct
Antisense RNA is:
(1) RNA that makes opposite sense
(2) RNA that investigators find confusing
(3) The non-coding strand of DNA molecule
(4) RNA that is complementary to certain mRNA
Which of the following statements is false?
| I. | Insulin was originally extracted from pancreas of slaughtered pigs and cattle |
| II. | Animal insulin is difficult to obtain |
| III. | Animal insulin is identical to human insulin |
| IV. | Non-human insulin caused some patients to develop allergy |
| V. | Recombinant DNA allowed scientists to insert a human insulin gene into a bacterial expression vector |
| VI. | Recombinant insulin is actually obtained from E. coli bacterial cell |
1. Only I and II
2. Only III and IV
3. Only III
4. Only VI
Which step proved to be the main challenging obstacle in the production of human insulin by genetic engineering?
(1) Splitting A and B polypeptide chains
(2) Addition of C-peptide to pro-insulin
(3) Getting insulin assembled into mature form
(4) Removal of C-peptide from active insulin
Which technique would you expect to be completely curative in SCID?
(1) Gene therapy in adult stage
(2) Gene therapy in embryonic stage
(3) Bone marrow transplantation
(4) Enzyme replacement therapy
For effective treatment of a disease:
(1) Early diagnosis is needed but understanding of its pathophysiology is not needed
(2) Early diagnosis is not needed but understanding of its pathophysiology is needed
(3) Early diagnosis and understanding of its pathophysiology are needed
(4) Neither early diagnosis nor understanding of its pathophysiology is needed
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