Q. No.How many of the given statements regarding insulin are correct?
I:
All diabetics require insulin from the very beginning.
II:
Insulin can be given orally to diabetics.
III.
Insulin extracted from pancreas of slaughtered cattle and pigs caused some patients to develop allergy.
IV.
Recombinant insulin was first prepared by Indian pharmaceutical giant Ranbaxy.
V.
The two polypeptide chains in the final structure of Insulin are joined by disulfide bonds.
VI.
DNA sequences corresponding to A and B chains of human insulin were introduced in plasmids of E.coli to produce insulin chains for preparing recombinant insulin.
1.
2
2.
3
3.
4
4.
5
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| Assertion (A): | Correction of a gene defect by gene therapy involves delivery of a normal copy of gene into the individual or embryo. |
| Reason (R): | The normal copy of gene delivered takes over the function of and compensates for the non-functional gene. |
| 1. | Both (A) and (R) are false. |
| 2. | (A) is true but (R) is false. |
| 3. | Both (A) and (R) are true but (R) does not explain (A). |
| 4. | Both (A) and (R) are true and (R) explains (A). |
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| Assertion (A): | Deficiency of the enzyme adenosine deaminase causes severe combined immunodeficiency. |
| Reason (R): | This disorder is caused due to the deletion of the gene for adenosine deaminase. |
| 1. | Both (A) and (R) are true but (R) does not explain (A). |
| 2. | (A) is true but (R) is false. |
| 3. | Both (A) and (R) are false. |
| 4. | Both (A) and (R) are true and (R) explains (A). |
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| I: | ADA deficiency is caused due to the deletion of the gene for adenosine deaminase. |
| II: | Bone marrow transplant and enzyme replacement therapy are completely curative. |
| III. | Lymphocytes transformed with cADA gene are permanent cure for the condition. |
| 1. | Only I and II | 2. | Only I |
| 3. | Only II and III | 4. | I, II and III |
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| I: | PCR is now used routinely to detect HIV in suspected AIDS patients. |
| II: | PCR is being used to detect mutations in genes in suspected cancer patients. |
| III. | PCR can detect infections only when symptoms are present. |
| 1. | Statement I is correct, Statement II is incorrect, Statement III is correct. |
| 2. | Statement I is incorrect, Statement II is correct, Statement III is correct. |
| 3. | Statement I is correct, Statement II is correct, Statement III is incorrect. |
| 4. | Statement I is incorrect, Statement II is incorrect, Statement III is correct. |
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| 1. | have had their DNA manipulated to possess and express an extra [foreign] gene. |
| 2. | are genetically modified with the use of foreign genes from a sexually compatible donor organism. |
| 3. | are produced by interspecific hybridisation. |
| 4. | are produced by inbreeding. |
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| I: | Transgenic animals can be specifically designed to allow study of how genes are regulated, and how they affect the normal functions of the body and its development. |
| II: | Transgenic animals cannot be used to serve as models for humans diseases so that investigation of new treatments for diseases is made possible. |
| III. | Transgenic animals can be specifically designed to allow study of complex factors involved in growth such as insulin like growth factor. |
| 1. | Statement I is correct, Statement II is incorrect, Statement III is correct |
| 2. | Statement I is incorrect, Statement II is correct, Statement III is correct |
| 3. | Statement I is correct, Statement II is correct, Statement III is incorrect |
| 4. | Statement I is incorrect, Statement II is incorrect, Statement III is correct |
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| Assertion (A): | Transgenic mice are being used to test the safety of polio vaccine. |
| Reason (R): | Monkeys are not reliable to test the safety of polio vaccine. |
| 1. | Both (A) and (R) are false. |
| 2. | Both (A) and (R) are true but (R) does not explain (A). |
| 3. | (A) is true but (R) is false. |
| 4. | Both (A) and (R) are true and (R) explains (A). |
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| I: | Transgenic animals are being used for testing toxicity of drugs. |
| II: | Transgenic animals are made that carry genes which make them more sensitive to toxic substances than non-transgenic animals. |
| 1. | Statement I is correct and Statement II is incorrect. |
| 2. | Both Statement I and Statement II are correct. |
| 3. | Both Statement I and Statement II are incorrect. |
| 4. | Statement I is incorrect and Statement II is correct. |
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| Assertion (A): | The manipulation of living organisms by the human race cannot go on any further, without regulation. |
| Reason (R): | Genetic modification of organisms can have unpredictable results when such organisms are introduced into the ecosystem. |
| 1. | Both (A) and (R) are true and (R) explains (A). |
| 2. | (A) is true but (R) is false. |
| 3. | Both (A) and (R) are true but (R) does not explain (A). |
| 4. | Both (A) and (R) are false. |
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