Assertion (A): | In most cases, recombinant therapeutics are safer than similar products isolated from non-human sources. |
Reason (R): | Recombinant therapeutics do not induce unwanted immunological responses. |
1. | Both (A) and (R) are True and (R) correctly explains (A). |
2. | (A) is True but (R) is False. |
3. | Both (A) and (R) are True but (R) does not explain (A). |
4. | Both (A) and (R) are False. |
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I: | All diabetics require insulin from the very beginning. |
II: | Insulin can be given orally to diabetics. |
III. | Insulin extracted from pancreas of slaughtered cattle and pigs caused some patients to develop allergy. |
IV. | Recombinant insulin was first prepared by Indian pharmaceutical giant Ranbaxy. |
V. | The two polypeptide chains in the final structure of Insulin are joined by disulfide bonds. |
VI. | DNA sequences corresponding to A and B chains of human insulin were introduced in plasmids of E.coli to produce insulin chains for preparing recombinant insulin. |
1. | 2 | 2. | 3 |
3. | 4 | 4. | 5 |
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Assertion (A): | Correction of a gene defect by gene therapy involves delivery of a normal copy of gene into the individual or embryo. |
Reason (R): | The normal copy of gene delivered takes over the function of and compensates for the non-functional gene. |
1. | Both (A) and (R) are False. |
2. | (A) is True but (R) is False. |
3. | Both (A) and (R) are True but (R) does not explain (A). |
4. | Both (A) and (R) are True and (R) explains (A). |
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Assertion (A): | Deficiency of the enzyme adenosine deaminase causes severe combined immunodeficiency. |
Reason (R): | This disorder is caused due to the deletion of the gene for adenosine deaminase. |
1. | Both (A) and (R) are True but (R) does not explain (A). |
2. | (A) is True but (R) is False. |
3. | Both (A) and (R) are False. |
4. | Both (A) and (R) are True and (R) explains (A). |
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I: | ADA deficiency is caused due to the deletion of the gene for adenosine deaminase. |
II: | Bone marrow transplant and enzyme replacement therapy are completely curative. |
III. | Lymphocytes transformed with cADA gene are permanent cure for the condition. |
1. | Only I and II | 2. | Only I |
3. | Only II and III | 4. | I, II and III |
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I: | PCR is now used routinely to detect HIV in suspected AIDS patients. |
II: | PCR is being used to detect mutations in genes in suspected cancer patients. |
III: | PCR can detect infections only when symptoms are present. |
1. | Statement I is correct, Statement II is incorrect, Statement III is correct. |
2. | Statement I is incorrect, Statement II is correct, Statement III is correct. |
3. | Statement I is correct, Statement II is correct, Statement III is incorrect. |
4. | Statement I is incorrect, Statement II is incorrect, Statement III is correct. |
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1. | have had their DNA manipulated to possess and express an extra [foreign] gene. |
2. | are genetically modified with the use of foreign genes from a sexually compatible donor organism. |
3. | are produced by interspecific hybridisation. |
4. | are produced by inbreeding. |
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I: | Transgenic animals can be specifically designed to allow study of how genes are regulated, and how they affect the normal functions of the body and its development. |
II: | Transgenic animals cannot be used to serve as models for humans diseases so that investigation of new treatments for diseases is made possible. |
III: | Transgenic animals can be specifically designed to allow study of complex factors involved in growth such as insulin like growth factor. |
1. | Statement I is correct, Statement II is incorrect, Statement III is correct |
2. | Statement I is incorrect, Statement II is correct, Statement III is correct |
3. | Statement I is correct, Statement II is correct, Statement III is incorrect |
4. | Statement I is incorrect, Statement II is incorrect, Statement III is correct |
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Assertion (A): | Transgenic mice are being used to test the safety of polio vaccine. |
Reason (R): | Monkeys are not reliable to test the safety of polio vaccine. |
1. | Both (A) and (R) are False. |
2. | Both (A) and (R) are True but (R) does not explain (A). |
3. | (A) is True but (R) is False. |
4. | Both (A) and (R) are True and (R) explains (A). |
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I: | Transgenic animals are being used for testing toxicity of drugs. |
II: | Transgenic animals are made that carry genes which make them more sensitive to toxic substances than non-transgenic animals. |
1. | Statement I is correct and Statement II is incorrect. |
2. | Both Statement I and Statement II are correct. |
3. | Both Statement I and Statement II are incorrect. |
4. | Statement I is incorrect and Statement II is correct. |
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