Q. No.Which kind of therapy was given in 1990 to a four-year-old girl with Adenosine Deaminase (ADA) deficiency?
(1) Gene therapy
(2) Chemotherapy
(3) Immunotherapy
(4) Radiation therapy
A permanent cure for ADA deficiency could be:
| 1. | Enzyme replacement therapy |
| 2. | Bone marrow transplant |
| 3. | Introduction of a functional ADA cDNA into lymphocytes |
| 4. | Introduction of gene isolated from marrow cells producing ADA into early embryonic cells |
Find the incorrect statement.
1. Gene therapy is a genetic engineering technique
used to treat disease at molecular level by
replacing defective genes with normal genes
2. Calcitonin is a medically useful recombinant
product in the treatment of infertility
3. Bt toxin is biodegradable insecticide obtained
from Bacillus thuringiensis
4. Trichoderma sp. is a biocontrol agent for fungal
diseases of plants
The first step of gene therapy would be
(1) Culture of the lymphocytes from patient's blood
(2) Using vector for transmitting gene
(3) cDNA was prepared
(4) cDNA was inserted directly into the cells
Gene therapy is not
(1) An attempt to correct a gene defect
(2) By which genes are inserted into an individual or embryo to take over the function of and compensate the non-functional gene.
(3) Genes are inserted into a person's cells and tissues to treat a disease
(4) Correction of environmental defect by inserting a gene
The last step of gene therapy would be
(1) The corrected lymphocytes are returned to the patients
(2) Culture of lymphocytes of the patient
(3) Introduction of correct gene in cultured cells
(4) Removal of corrected lymphocytes from culture
Which of the following therapies for ADA deficiency are not completely curative?
(1) Bone Marrow Transplantation
(2) Enzyme replacement Therapy
(3) Both A and B
(4) Both are completely curative
The permanent cure of gene therapy can be
(1) Cells isolated from bone marrow in an adult were cultured and transformed with corrected gene
(2) Cells isolated from thymus in an adult were cultured and transformed with corrected gene
(3) Cells isolated from bone marrow in an embryo were cultured and transformed with corrected gene
(4) Genes isolated from bone marrow were introduced into the cells at early embryonic stage
All of the following statements are correct in respect of gene therapy, except
1. It allows correction of genetic defect in embryonic stage only
2. The gene is inserted into cells and tissues to treat a disease
3. Delivery of a normal gene into cell takes over the function of and compensate for the non-functional gene
4. As a step towards gene therapy to treat ADA deficiency, ADAcDNA is introduced into cultured lymphocytes of the patient and subsequently returned to him/her.
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