- 1(current)
Q. No.In which disorder, change of single base pair in the gene for beta globin chain results in change of glutamic acid to valine?
| 1. | Thalassemia | 2. | Sickle cell anemia |
| 3. | Haemophilia | 4. | Phenylketonuria |
Subtopic: Mendelian Disorders: Sickle Cell Anemia |
85%
Level 1: 80%+
NEET - 2023
Hints
Select the correct statements about sickle cell anemia:
Choose the correct answer from the options given below:
| A: | There is a change in the gene for beta-globin |
| B: | In beta-globin, there is a valine in place of Lysine |
| C: | It is an example of point mutation |
| D: | In the normal gene, U is replaced by A |
Choose the correct answer from the options given below:
| 1. | (B), (C) and (D) only | 2. | (B) and (D) only |
| 3. | (A), (B) and (D) only | 4. | (A) and (C) only |
Subtopic: Mendelian Disorders: Sickle Cell Anemia |
82%
Level 1: 80%+
NEET - 2023
Hints
In a cross between a male and female, both heterozygous for sickle cell anaemia gene, what percentage of the progeny will be diseased?
| 1. | 25% | 2. | 100% |
| 3. | 50% | 4. | 75% |
Subtopic: Mendelian Disorders: Sickle Cell Anemia |
58%
Level 3: 35%-60%
NEET - 2021
Hints
Select the correct match:
| 1. | Phenylketonuria | Autosomal dominant trait |
| 2. | Sickle cell anemia | Autosomal recessive trait chromosome - 11 |
| 3. | Thalassemia | X linked |
| 4. | Haemophilia | Y linked |
Subtopic: Mendelian Disorders: Sickle Cell Anemia |
69%
Level 2: 60%+
NEET - 2020
Hints
Pick out the correct statements:
| I: | Haemophilia is a sex-linked recessive disease. |
| II: | Down’s syndrome is due to aneuploidy. |
| III: | Phenylketonuria is an autosomal recessive gene disorder. |
| IV: | Sickle cell anaemia is an X-linked recessive gene disorder |
1. II and IV are correct
2. I, III and IV are correct
3. I, II and III are correct
4. I and IV are correct
2. I, III and IV are correct
3. I, II and III are correct
4. I and IV are correct
Subtopic: Mendelian Disorders: Sickle Cell Anemia | Mendelian Disorders | Mendelian Disorders: Hemophilia | Non - Disjunction & Aneuploidy |
81%
Level 1: 80%+
NEET - 2016
Hints
Sickle cell anaemia is:
| 1. | an autosomal linked dominant trait |
| 2. | caused by substitution of valine by glutamic acid in the globin chain of haemoglobin |
| 3. | caused by a change in base pair of DNA |
| 4. | characterized by elongated sickle like RBCs with a nucleus |
Subtopic: Mendelian Disorders: Sickle Cell Anemia |
54%
Level 3: 35%-60%
AIPMT - 2009
Hints
Sickle cell anaemia is due to:
| 1. | Change of Amino Acid in α-chain of Haemoglobin. |
| 2. | Change of Amino Acid in β-chain of Haemoglobin. |
| 3. | Change of Amino acid in both α and β chains of Haemoglobin. |
| 4. | Change of Amino acid either α or β chain of Haemoglobin. |
Subtopic: Mendelian Disorders: Sickle Cell Anemia |
82%
Level 1: 80%+
AIPMT - 2001
Hints
- 1(current)
Q. No.
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