Transition state structure of the substrate formed during an enzymatic reaction is:
| 1. | permanent but unstable |
| 2. | transient and unstable |
| 3. | permanent and stable |
| 4. | transient but stable |
| I: | if it is an exothermic or spontaneous reaction. |
| II: | it is an endothermic or energy requiring reaction. |
| 1. | Only I is correct |
| 2. | Only II is correct |
| 3. | Both I and II are correct |
| 4. | Both I and II are incorrect |