The point mutation leading to sickle cell anaemia occurs:
1. at sixth position in the beta chain of haemoglobin
2. at sixth position in the alpha chain of haemoglobin
3. at sixth position in the beta chain of myoglobin
4. at sixth position in the alpha chain of myoglobin
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NEET MCQ Books for XIth & XIIth Physics, Chemistry & Biology
The point mutation in sickle cell anaemia leads to a change in codon. Identify the correct change:
(1) UGA to UAA
(2) GUG to GAG
(3) GAG to GUG
(4) UAA to UGA
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NEET MCQ Books for XIth & XIIth Physics, Chemistry & BiologySickle cell anaemia results from.
1. A chromosomal aberration
2. Non disjunction of autosome
3. A point mutation
4. Blood transfusion reaction
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NEET MCQ Books for XIth & XIIth Physics, Chemistry & Biology
In sickle cell anaemia, the mutant haemoglobin molecule undergoes
(1) Polymerisation under low oxygen tension causing that changes the shape of the RBC to sickle like structure
(2) Depolymerisation under low oxygen tension causing that changes the shape of the RBC to sickle like structure
(3) Denaturation under high oxygen tension causing that changes the shape of the RBC to sickle like structure
(4) Denaturation
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NEET MCQ Books for XIth & XIIth Physics, Chemistry & BiologyA normal woman, whose father had colour blindness, married a normal man. What is the chance of occurrence of colour blindness in the progeny?
1. 25%
2. 50%
3. 100%
4. 74%
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NEET MCQ Books for XIth & XIIth Physics, Chemistry & BiologyWhich of the following genotypes could cause Sickle cell anaemia?
(1) Hbˢ + Hbᴬ
(2) Hbᴬ+ Hbᴬ
(3) Hbˢ + Hbˢ
(4) Both ‘A’ and ‘C’.
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NEET MCQ Books for XIth & XIIth Physics, Chemistry & BiologyIn the given below figure what does (a) and (b) represent
1. GAG, Glumatic acid
2. GUG, Valine
3. GAG, Valine
4. GUG, Glumatic acid
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NEET MCQ Books for XIth & XIIth Physics, Chemistry & BiologyGiven below is the initial amino acids of the beta chain of a hemoglobin molecule. What will be true about this hemoglobin molecule ?
1. | The RBCs carrying this molecule will undergo sickling at high oxygen tension |
2. | The RBCs carrying this molecules will undergo sickling at low oxygen tension |
3. | There will be a quantitative decrease in the synthesis of this molecule |
4. | This is normal beta chain of the hemoglobin molecule |
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NEET MCQ Books for XIth & XIIth Physics, Chemistry & BiologyIn a person suffering from sickle-cell anaemia, the template strand of sickle-cell Hb(s) gene has a specific nitrogenous base sequence that codes for valine amino acid. The base sequence on template strand is
1. 5’-CAC-3’
2. 5’-GAG-3’
3. 3’-CAG-5’
4. 3’-CAC-5’
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NEET MCQ Books for XIth & XIIth Physics, Chemistry & BiologyMatch the following
Column-l Column-ll
a. Haemophilia i. Rudimentary ovaries
b. Sickle cell anaemia ii. X-linked recessive
c. Turner's syndrome iii. Gynaecosmastia
d. Klinefelter's iv. Autosomal recessive
syndrom
a. a(ii), b(iv), c(i), d(iii)
b. a(ii), b(iv), c(iii), d(i)
c. a(iv), b(ii), c(i), d(iii)
d. a(iv), b(i), c(ii), d(iii)
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NEET MCQ Books for XIth & XIIth Physics, Chemistry & Biology