Given below are two statements: 

Assertion (A): In presence of an enzyme, the substrate molecule can be attacked by the reagent effectively.
Reason (R): Active sites of enzymes hold the substrate molecule in a suitable position.

1. Both (A) and (R) are true and (R) is the correct explanation of (A).
2. Both (A) and (R) are FALSE.
3. (A) is true but (R) is false.
4. (A) is false but (R) is true.